"Reliable Analysis, Accurate Results"

GAAS Analytical specializes in developing robust analytical methods and providing analytical services that are guaranteed to comply with current regulatory mandates and scientific standards.

About GAAS Analytical

GAAS Analytical, the service branch of GAAS Corporation was established in 2008 to capitalize on the extensive instrumental analytical knowledge and experience of one of the founders of GAAS Corporations, Dr. Aniko Solyom. GAAS Analytical is an independent contract testing laboratory of natural products, botanical drugs, phytochemicals and dietary supplements, including raw materials, intermediates and finished products. We provide high quality analytical services, including routine testing, analytical method development & validation and contract research & development, to medium and small businesses and educational institutes.

Our methods are in compliance with accepted national and international standard methods including US Pharmacopoeia (USP), European Pharmacopeia (EP), the Association of Analytical Chemists (AOAC), and the Foods Chemical Codex (FCC). We are also licensed by the DEA to test controlled substances.

GAAS Analytical offers analytical testing according to cGMP regulations for identity and purity using mainly HPLC instrumentation. We routinely participate in the Dietary Supplement Laboratory Quality Assurance Program (DSQAP) established by the National Institute of Standards and Technology (NIST) in 2007 with support from the Office of Dietary Supplements (ODS) at the National Institutes of Health. The DSQAP is an extension of collaborative ongoing efforts among ODS, NIST, USDA, and FDA to improve the tools for evaluating dietary supplements. The DSQAP enables participants to improve the accuracy and precision of their measurements in dietary supplement ingredients and finished products.

Our standard analytical reports include not only the end results, but also supporting documents, such as the analytical method(s) used, calibration curves, actual chromatograms and relevant statistics. The FDA regulation of dietary supplements requires companies to prove that the analytical methods they use are scientifically valid - our report satisfies this requirement. This detailed report is part of our standard service; we don't charge extra fee for it (see a sample report).


Our Team

Anikó M. Sólyom, Ph.D.

The CEO and founder of GAAS, Anikó M. Sólyom has more than 30 years of comprehensive experience in analytical method development and validation, using a wide variety of analytical techniques. Her expertise is in development and validation of analytical methods with particular emphasis on HPLC, LC-MS applications and bioactivity guided preparative separation of complex mixtures and analysis of biological samples and dietary supplements that she gained working on drug development and contract analysis both in academia and industry. In addition to HPLC technique she has significant experience with atomic absorption spectroscopy, inductively coupled plasma emission spectroscopy, photoacoustic spectroscopy, UV-Vis spectroscopy, elemental analysis, mass spectrometry, gas chromatography, GC-MS, LC-MS and NMR. She also has experience conducting absorption, distribution and elimination studies on animals.

Before founding GAAS Corporation, Anikó served as director of the Analytical Core at an NIH funded Botanical Center (Arizona Center for Phytomedicine Research). The Facility focused on quantitation and identification of natural products and dietary supplements, particularly anti-inflammatory compounds from turmeric, ginger and boswellia. She developed methods to analyze these compounds from the plant materials, extracts, commercially available dietary supplements and from different biological matrices.

She also managed analytical laboratories working under GLP conditions. For years she served as the Project Manager at the University of Arizona for the "Studies of Chemical Disposition in Mammals" government contract (NO1-ES-45529, NIH/NIEHS), a multi-million dollar project. She also worked for Oncothyreon/ProlX Pharmaceuticals, a company specializing in cancer drug development, as the Manager of Analytical Services. Her duties included developing and validating new assay methods according to cGLP regulations, to quantify novel cancer drugs in plasma and urine using QQQ LC/MS technique; identifying metabolites of new cancer drugs in plasma and urine using TOF LC/MS technique and calculating pharmacokinetic parameters.

She is an active member of AOAC International; she joined the organization in 2002. Currently she is member of AOAC’s Stakeholder Panel on Dietary Supplements responsible for developing, approving, and implementing standards for high priority dietary ingredients. She has participated in multiple AOAC organized collaborative studies (glucosamine, ginkgo, saw palmetto) in order to validate analytical methods to be used by the dietary supplement industry (see References). She was Horwitz advisor of AOAC until the restructuring the Official Methods of Analysis (OMA) process in January 2008, when the role of method advisors and Horwitz advisors was retired. As a former Horwitz advisor she is familiar with the AOAC Official Methods (OMA) program. For 5 years she has been serving as member of the Presidential Task Force on Dietary Supplements of AOAC, and also served as member of Expert Review Panels of AOAC.

George Z. Angeli, Ph.D.

The President and co-founder of GAAS Corporation, George Z. Angeli has extensive experience in engineering management, systems engineering and project management for projects ranging from small to very large.

As Systems Engineering Manager, he is the chief technical leader of a $650M federally funded project, the Large Synoptic Survey Telescope. His responsibilities span the entire project, including all the major subsystems and the whole life cycle of the project from the onset of construction to commissioning and handover to operations. Besides integrating the various technical contributions into an integrated system through interface design and specification, modeling, and simulations, he is also responsible for the technical direction and day-to-day priorities for the Commissioning phase of the project.

Formerly he was Head of Systems Engineering of the Thirty Meter Telescope Observatory, an international partnership between the USA, Canada, Japan, India, and China to build an Extremely Large Optical Telescope (ELT). Before that he was the project manager of a team developing real time, phase shifting interferometers at WYKO. During his professional career he led the design or contributed to the development of numerous optical and electronic instruments.

He is the returning chair of the "Modeling, Systems Engineering, and Project Management for Astronomy" international conference organized by SPIE (Society of Photo-Optical Instrumentation Engineers) in every other year. He is on the Editorial Board of the "Journal of Astronomical Telescopes, Instruments, and Systems"; he has 60+ professional publications.

Gabor G. Angeli

Gabor Angeli is the Chief Information Officer of GAAS Corporation. He currently manages the GAAS website and associated e-mail accounts, and the GAAS data servers. He also oversees and manages the security of the GAAS internal network. Gabor is a graduate of The University of California, Berkeley and is currently pursuing a Ph.D. in computer science at Stanford University.


Our Laboratory

GAAS Corporation's facility is located in the "Commerce Plaza" in Tucson, Arizona. However, we service clients throughout North America, including clients from Canada. The laboratory is strategically located near The University of Arizona, with convenient freeway access to I-10. Commerce Plaza is a modern office-industrial park conveniently located near the center of the greater Tucson metropolitan area. Each of the 39 office-warehouse units is 1,200 square feet and has its own office, bathroom and 10' X 10' roll-up door at grade level. Commerce Plaza was built to provide incubator rental space for start-up businesses as well as to provide the flexibility of being able to accommodate long-term tenants. A permanent on-site manager ensures that the property is well maintained.

GAAS Corporation's facility consists of 200 square feet of office, 200 square feet for analytical instrumentation and 800 square feet sample preparation and storage space. The facility is protected with a continuously monitored security system and equipped with features required for the health & safety of our employees. The laboratory was designed and constructed for the efficient production of high quality analytical services.

The laboratory is equipped with an Agilent 1200 series Rapid Resolution HPLC system, including SL binary pump, vacuum degasser, thermostatted autosampler, thermostatted column compartment and diode array detector. All instrumentation and computer components are protected against power spikes and outages by an emergency uninterrupted power backup system.

The laboratory is also equipped with the necessary laboratory equipment: UV-vis spectrophotometer, micro- and analytical balances, Buchi R-200 rotary evaporator, benchtop concentrator, solid phase extraction (SPE) apparatus,, water purification system, furnace oven, temperature controlled water bath, centrifuges, vacuum oven, ultra-low temperature freezer, and common laboratory equipment (hot plates, oven, stirrers, shakers, ultrasonic cleaner, mini centrifuge, pH meter, vacuum pumps, refrigerator) to perform the preparation and analysis of samples.

In addition to GAAS' own facility, the company has access on a fee basis to the services of the University of Arizona.


Our Certifications And Publications

GAAS maintains certificates for cGMP analysis and analysis of controlled substances. In addition, we make a conscious effort foster trust with transparency, and report our scores on the NIST sponsored Dietary Supplement Laboratory Quality Assurance Program (DSQAP). Additionally Aniko publishes regularly in peer-reviewed journals and conference proceedings, listed under our publications.

Certifications

GAAS Analytical offers analytical testing according to cGMP regulations; Aniko Solyom completed the training on 21 CFR 58, Good Laboratory Practice for Non-Clinical Laboratory Studies.

GAAS Analytical regularly participates in the NIST established Dietary Supplement Laboratory Quality Assurance Program (DSQAP). This is a program to assess the accuracy of a lab's analysis: samples are sent to the lab, and an evaluation is given on how close the lab's reported results are to the gold standard determined by NIST. GAAS regularly provides analysis within the target and consensus range on these exercises. We make all of our results available here:

We are also licensed by the DEA to test controlled substances.

Publications

  1. "Did that bilberry powder come from bilberries, or something else?" - Invited talk at the Pacific Southwest Section of AOAC International (link)
  2. "Bioavailabilty Studies of Curcuminoids: Lessons Learned and the Need for Labeled Reference Materials" - Invited talk at the 12th Annual Oxford International Conference on the Science of Botanicals (link)
  3. "Bioavailabilty Studies of Curcuminoids: Lessons Learned and the Need for Labeled Reference Materials" - Peer reviewed paper published in Planta Medica (link)
  4. "Isolation, identification, and quantification of potential defensive compounds in the viceroy butterfly and its larval host-plant, Carolina willow" - Peer reviewed paper published in Journal of Chem. Ecology in 2007 (link)
  5. "Curcuminoids form reactive glucuronides in vitro" - Peer reviewed paper published in Journal of Agricultural and Food Chemistry in 2007 (link)
  6. "The effects of dose, route, and repeated dosing on the disposition and kinetics of tetrabisphenol A in male F-344 rats" - Peer reviewed paper published in Toxicological Sciences in 2007 (link)
  7. "Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis" - Peer reviewed paper published in Journal of Natural Products in 2006 (link)
  8. "Metabolism of curcuminoids in tissue slices and subcellular fractions from rat liver" - Peer reviewed paper published in Journal of Agricultural and Food Chemistry in 2006 (link)
  9. "Efficacy and mechanism of action of turmeric supplements in the treatment of rheumatoid arthritis: a translational investigation" - Peer reviewed paper published in Arthritis and Rheumatism in 2006 (link)
  10. "Marker compound=Major compound?" - Poster presented by Aniko M. Solyom at AHSC in Tucson, Arizona, October 2006 (link)
  11. "The effect of turmeric extracts on inflammatory mediator production" - Peer reviewed paper published in Phytomedicine in 2005 (link)
  12. "Determination of glucosamine in raw materials and dietary supplements containing glucosamine sulfate and/or glucosamine hydrochloride by high-performance liquid chromatography with FMOC-Su derivatization: Collaborative study" - Peer reviewed paper published in Journal of AOAC International in 2005 (link)
  13. "Characterization of gingerol-related compounds in ginger rhizome (Zingiber officinale Rosc.) by high performance liquid chromatography/electrospray ionization mass spectrometry" - Peer reviewed paper published in Rapid Communications in Mass Spectrometry in 2005 (link)
  14. "Changes in chemical composition and in vitro anti-inflammatory activity of turmeric oil during long term storage" - Poster presented by Aniko M. Solyom at the 119th AOAC International Annual Meeting and Exposition, Orlando, Florida, 2005 (link)
  15. "LC/MS analysis of glucuronides of curcuminoids and their reductive metabolites" - Poster presented by Aniko M. Solyom at the 119th AOAC International Annual Meeting and Exposition, Orlando, Florida, 2005 (link)
  16. "Analysis of the viceroy butterfly defensive compounds using high performance liquid chromatography with diode array and ion trap mass spectrometric detection" - Poster presented by Aniko M. Solyom at the 119th AOAC International Annual Meeting and Exposition, Orlando, Florida, 2005 (link)
  17. "Validated Analytical Methods: The Case for Quality Measurements" - Article in AOAC International, January 2005 (link)
  18. "Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induces PGE2 production" - Peer reviewed paper published in Phytochemistry (link)
  19. "Absorption and elimination of D&C Red 28 in male F-344 rats" - Peer reviewed paper published in Food and Chemical Toxicilogy in 2004 (link)
  20. "Extraction and analysis of fresh ginger root and ginger dietary supplement" - Poster presented by Gabor G. Angeli at the 118th AOAC International Annual Meeting and Exposition, St. Louis, Missouri, 2004 (link)
  21. "Development of an LC/MS/MS method to separate and analyze curcuminoids, their metabolites and degradation Products" - Poster presented by Aniko M. Solyom at the 118th AOAC International Annual Meeting and Exposition, St. Louis, Missouri, 2004 (link)
  22. "Analysis of turmeric extracts using liquid chromatography with ion trap mass spectrometric detection" - Poster presented by Aniko M. Solyom at the 118th AOAC International Annual Meeting and Exposition, St. Louis, Missouri, 2004 (link)
  23. "Quantification of the curcuminoids content in bulk wholesale and retail dietary supplements" - Poster presented by Amber S. Roberts at the Undergraduate Research Posters on the Hill event, organized by The council on Undergraduate Research, Washington D.C, 2004 (link)
  24. "Studies on the stability of turmeric constituents" - Peer reviewed paper published in Journal of Food Engineering in 2003 (link)
  25. "Quantification of the curcuminoids content in bulk wholesale and retail dietary supplements" - Poster presented by Aniko M. Solyom at the117th AOAC International Annual Meeting and Exposition, Atlanta, Georgia, 2003 (link)
  26. "Ginger: What's in the bottle?" - Poster presented by Aniko M. Solyom at the 117th AOAC International Annual Meeting and Exposition, Atlanta, Georgia, 2003 (link)
  27. "Development of solid phase extraction (SPE) method for the analysis of curcuminoids" - Poster presented by Veronica P. Rodriguez at the 117th AOAC International Annual Meeting and Exposition, Atlanta, Georgia, 200 (link)
  28. "Bioactivity guided separation of raw turmeric (Curcuma longa)" - Poster presented by Aniko M. Solyom at the 41th Annual Meeting of the American Society of Toxicology, Nashville, Tennessee, 2002 (link)
  29. "Chemical Stability of Curcuminoids and their estrogenic activity in Ishikawa cells" - Poster presented by Aniko M. Solyom at the 41th Annual Meeting of the American Society of Toxicology, Nashville, Tennessee, 2002 (link)
  30. "Pharmacokinetics and disposition of D&C Red No. 28 in male Fischer-344 rats" - Poster presented by Aniko M. Solyom at the 41th Annual Meeting of the American Society of Toxicology, Nashville, Tennessee, 2002 (link)
  31. "The in vivo absorption distribution and excretion of 14C-methyleugenol in male F-344 rats after topical application" - Poster presented by Aniko M. Solyom at the 40th Annual Meeting of the American Society of Toxicology, San Francisco, California, 2001 (link)
  32. "Determination of ammonia using carbon dioxide laser" - Photoacoustic spectroscopy compared with conventional spectrophotometry - Peer reviewed paper published in The Analyst in 1992 (link)
  33. "Calibration of a windowless photoacoustic cell for detection of trace gases" - Peer reviewed paper published in Analytical Chemistry in 1992 (link)